P02.146. Mindfulness based stress reduction in adults with mild cognitive impairment: a pilot study using fMRI

Results The mean (SD) age was 74 (7); baseline Mini-Mental State Exam score was 27.2 (1.5); class attendance was 88%; and home practice was 26.1 minutes/day (19.6). No adverse events were reported. At 8 weeks, episodic memory was not improved in adults randomized to MBSR compared to the control (median change [Q1, Q3] from baseline, Rey Auditory Verbal Learning Test total recall -2.5 [-5.5, 0] vs. +1 [-1, 4], p=.24). Non-significant trends that suggested improvement with MBSR were detected for change from baseline for MBSR vs. control for AD Assessment Scalecognitive subscale (-0.5, [-4, 0.5] vs. 0 [-1, 2], p=0.46); Resilience Scale (+7 [2, 21] vs. -2 [-9, 0], p=0.18); QOL-AD (+2 [-1, 3] vs. 0 [-1, 0], p=0.25); Perceived Stress Scale (-1 [-6,0] vs. 0 [-4, 2], p=.46). Compared with the control group, the regional homogeneity of the left hippocampus and putamen/inferior frontal gyrus were significantly enhanced in the MBSR group. Data for 6 months are not yet available.